Status:
COMPLETED
Comparison of Alveolar Macrophages in Healthy Individuals Versus Individuals With COPD
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Pulmonary Disease, Chronic Obstructive
Lung Diseases, Obstructive
Eligibility:
All Genders
18-80 years
Brief Summary
This study group forms the normal subject control group in an experiment designed to determine whether the alveolar macrophages (AMø) of patients with chronic obstructive pulmonary disease (COPD) show...
Detailed Description
BACKGROUND: COPD is one of the most pressing healthcare problems facing our nation. Acute exacerbations of COPD (AE-COPD) are responsible for the bulk of healthcare costs, and much of the morbidity a...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Healthy individuals with normal pulmonary function as defined by AmericanThoracic Society criteria (entry spirometry)
- Exclusion criteria:
- Unstable cardiovascular disease
- Other systemic disease in which survival of more than 2 years is unlikely
- Mental incompetence or active psychiatric illness
- Currently taking more than 20 mg/day of Prednisone
- Participation in another experimental protocol within 6 weeks of study entry
- Asthma
- Cystic fibrosis
- Clinically significant bronchiectasis
- Lung cancer
- Other inflammatory or fibrotic lung disease
Exclusion
Key Trial Info
Start Date :
September 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 1 2010
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT00281203
Start Date
September 1 2005
End Date
July 1 2010
Last Update
July 16 2013
Active Locations (1)
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1
University of Michigan at Ann Arbor
Ann Arbor, Michigan, United States, 48105