Status:
COMPLETED
Innate and Adaptive Immunity in Individuals Experiencing Chronic Obstructive Pulmonary Disease Exacerbations
Lead Sponsor:
University of Michigan
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Pulmonary Disease, Chronic Obstructive
Lung Diseases
Eligibility:
All Genders
40-80 years
Brief Summary
The purpose of this study is to determine whether there is a statistical association between the changes from baseline in the levels of two cytokines interleukin (IL)-17A and IL-6 in the sputum of pat...
Detailed Description
BACKGROUND: COPD is one of the most pressing healthcare problems facing our nation. AE-COPD is responsible for the bulk of healthcare costs and much of the morbidity and decline in health status amon...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Diagnosis of COPD (following American Thoracic Society guidelines) and/or chronic bronchitis
- Forced Expiratory Volume in 1 second of less than 70% predicted value after bronchodilator
- Current or former smokers with more than 20 pack-years
- Daily productive cough for 3 months of the year for 2 consecutive years
- At least one AE-COPD requiring medical attention in each year for the previous 3 years
- Willingness to participate in follow-up studies defined in the protocol
- Exclusion criteria:
- Unstable cardiovascular disease
- Other systemic disease in which survival of more than 2 years is unlikely
- Mental incompetence or active psychiatric illness
- Currently taking more than 20 mg/day of Prednisone
- Participation in another experimental protocol within 6 weeks of study entry
- Asthma
- Cystic fibrosis
- Clinically significant bronchiectasis
- Lung cancer
- Other inflammatory or fibrotic lung disease
Exclusion
Key Trial Info
Start Date :
September 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00281216
Start Date
September 1 2005
End Date
September 1 2010
Last Update
January 29 2016
Active Locations (1)
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1
University of Michigan at Ann Arbor
Ann Arbor, Michigan, United States, 48105