Status:
UNKNOWN
Combination Chemotherapy With or Without Radiation Therapy in Treating Children With Brain Tumors
Lead Sponsor:
Children's Cancer and Leukaemia Group
Conditions:
Brain and Central Nervous System Tumors
Neuroblastoma
Eligibility:
All Genders
Up to 3 years
Phase:
PHASE2
Brief Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination ch...
Detailed Description
OBJECTIVES: * Determine the response rate in children under 36 months of age with primary brain or brain stem tumors treated with vincristine, methotrexate, carboplatin, cyclophosphamide, and cisplat...
Eligibility Criteria
Inclusion
- DISEASE CHARACTERISTICS:
- Diagnosis of 1 of the following:
- Brain stem tumor (histological confirmation not required)
- Histologically confirmed primary intracranial brain tumor of 1 of the following histologies:
- Anaplastic (malignant) astrocytoma
- Glioblastoma
- Anaplastic (malignant) oligodendroglioma
- Ependymoma
- Anaplastic (malignant) ependymoma
- Anaplastic (malignant) oligoastrocytoma
- Choroid plexus carcinoma
- Astroblastoma
- Polar spongioblastoma
- Gliomatosis cerebri
- Anaplastic (malignant) ganglioglioma
- Pineoblastoma
- Mixed pineocytoma or pineoblastoma
- Medulloepithelioma
- Neuroblastoma
- Ependymoblastoma
- Primitive neuroectodermal tumors (PNETs), including medulloblastoma or cerebral or spinal PNETs
- Has undergone surgery or biopsy of the tumor within the past 2-4 weeks
- PATIENT CHARACTERISTICS:
- No concurrent unrelated disease, including hematological or renal disease, that would preclude study treatment
- PRIOR CONCURRENT THERAPY:
- No prior chemotherapy or radiotherapy
- Prior steroids allowed
- No concurrent steroids as anti-emetics
- Concurrent steroids allowed for control of tumor-related symptoms
Exclusion
Key Trial Info
Start Date :
June 1 1992
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00281905
Start Date
June 1 1992
Last Update
September 20 2013
Active Locations (21)
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1
Our Lady's Hospital for Sick Children
Dublin, Ireland, 12
2
Birmingham Children's Hospital
Birmingham, England, United Kingdom, B4 6NH
3
Institute of Child Health at University of Bristol
Bristol, England, United Kingdom, BS2 8AE
4
Addenbrooke's Hospital at Cambridge University Hospitals NHS Foundation Trust
Cambridge, England, United Kingdom, CB2 2QQ