Status:
COMPLETED
MR Assessment of Brain Function Altered by Lead Exposure
Lead Sponsor:
National Institute of Environmental Health Sciences (NIEHS)
Conditions:
Lead Exposure
Eligibility:
All Genders
19-26 years
Brief Summary
Exposure to lead during pregnancy, infancy, and childhood increases the individual likelihood of impaired school performance, increased impulsiveness, aggression, and delinquent behavior. Disorders th...
Detailed Description
Overview of Imaging All MRI and MRS investigations will be acquired on a 1.5 clinical MR scanner. The MRI and MRS procedures will take approximately a half-hour to complete. Subjects also having fMRI...
Eligibility Criteria
Inclusion
- Participant in the Cincinnati Lead Study.
- Age range of at least 18 years with an upper limit of 25 years.
- Negative history for metabolic, neurologic, cardiac disease.
- Negative family history for metabolic or neurologic disease (in first-degree relatives only) to include genetic disorders.
Exclusion
- Presence of an implant such as a hearing aid, cochlear implant, pacemaker or neuro-stimulator containing electrical circuitry or generating electrical signals or having moving metal parts.
- Presence of metal implants, orthopedic pins or plates above the level of the waist.
- Presence of orthodontic braces.
- Subjects who demonstrate or express noticeable anxiety and/or cannot readily communicate with personnel operating the MR equipment will be excluded.
- Pregnancy.
Key Trial Info
Start Date :
October 1 2002
Trial Type :
OBSERVATIONAL
End Date :
September 1 2006
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT00283647
Start Date
October 1 2002
End Date
September 1 2006
Last Update
April 14 2015
Active Locations (1)
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1
Cincinnati Children's Hospital Medical Center, Dept. of Radiology and the Imaging Research Center
Cincinnati, Ohio, United States, 45229