Status:
COMPLETED
PET Imaging of Brain Peripheral Benzodiazepine Receptors
Lead Sponsor:
National Institute of Mental Health (NIMH)
Conditions:
Healthy Volunteer
Eligibility:
All Genders
18-65 years
Phase:
PHASE1
Brief Summary
This study will use positron emission tomography (PET) and magnetic resonance imaging (MRI) to measure peripheral benzodiazepine receptors (PBRs) in the brain. PBRs were initially found in peripheral ...
Detailed Description
The peripheral benzodiazepine receptor (PBR) is distinct from central benzodiazepine receptors associated with GABA(A) receptors. Although PBR was initially identified in peripheral organs such as kid...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- All subjects must be healthy and aged 18-65 years.
- EXCLUSION CRITERIA:
- Current psychiatric illness, substance abuse or severe systemic disease based on history and physical exam.
- ECG with clinically significant abnormalities. Any existing physical exam and ECG within one year will be reviewed and if none already exists in the chart, these will be obtained and reviewed.
- Laboratory tests with clinically significant abnormalities.
- Prior participation in other research protocols or clinical care in the last year such that radiation exposure would exceed the annual limits.
- Pregnancy and breast feeding.
- Claustrophobia.
- Presence of ferromagnetic metal in the body or heart pacemaker.
- Positive HIV test.
- A history of brain disease.
Exclusion
Key Trial Info
Start Date :
January 26 2006
Trial Type :
INTERVENTIONAL
End Date :
October 2 2007
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00283920
Start Date
January 26 2006
End Date
October 2 2007
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892