Status:
COMPLETED
The Effect of Obesity on Lung Functioning
Lead Sponsor:
National Jewish Health
Conditions:
Obesity
Asthma
Eligibility:
All Genders
18+ years
Brief Summary
This research study is looking at the effects of weight loss, due to surgery or structured weight-loss program on lung function, inflammation in your body and lungs, asthma and asthma symptoms. This s...
Eligibility Criteria
Inclusion
- Adults (≥18yr) who report a physician's diagnosis of asthma and have taken any asthma medication within the last 2 weeks.
- Obesity (Body Mass Index (BMI) ≥40, or ≥35 with comorbidities, as per published guidelines for qualification for bariatric surgery).
- Planned weight-loss surgery or structured weight-loss plan.
Exclusion
- Tobacco use within one month.
- Qualifying lung-functioning.
- Qualifying oxygen saturation levels.
- Use of systemic corticosteroids (Prednisone) within one month.
- Presence of another chronic lung disease besides asthma (COPD, bronchiectasis, ILD, sarcoidosis, etc).
- Presence of another chronic systemic inflammatory disease (rheumatoid arthritis or other connective-tissue disease, chronic infection such as osteomyelitis, inflammatory bowel disease, chronic active hepatitis, etc). Subjects with osteoarthritis, stable coronary artery disease, hypertension, or diabetes mellitus will not be excluded.
- Presence of malignant neoplasm within the last 3 years (with the exception of non-melanoma skin cancer).
- Clinically significant left or right ventricular dysfunction.
- Severe pulmonary hypertension (high blood pressure).
- Untreated obstructive sleep apnea:
- Subjects with a current diagnosis of sleep apnea not being treated with CPAP or BiPAP will be excluded.
- Subjects with a current diagnosis of sleep apnea being treated adequately (as determined by the investigators) will be included.
- Prader-Willi syndrome
- A known endocrinopathy causing obesity (e.g., Cushing's Syndrome).
Key Trial Info
Start Date :
November 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 1 2007
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00284895
Start Date
November 1 2005
End Date
November 1 2007
Last Update
March 29 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Jewish Medical and Research Center
Denver, Colorado, United States, 80206