Status:
COMPLETED
Moderate Alcohol Consumption, Risk of Cardiovascular Disease and Type 2 Diabetes: Influence of Alcohol Oxidation
Lead Sponsor:
TNO
Conditions:
Cardiovascular Disease
Type 2 Diabetes
Eligibility:
FEMALE
40-65 years
Phase:
NA
Brief Summary
Moderate alcohol consumption is associated with a decreased risk of cardiovascular disease and type 2 diabetes. The association of alcohol consumption with cardiovascular disease is mediated by a func...
Detailed Description
Objectives : To investigate the effect of moderate alcohol consumption and influence of genetic variation of ethanol oxidation on: * PPAR-γ activated gene expression * Markers of coronary heart dise...
Eligibility Criteria
Inclusion
- Healthy women aged 40 to 65 years
- Absence of menstrual period for at least 2 years
- Homozygotes for the ADH1C\*1 or ADH1C\*2 allele of ADH1C I349V polymorphism
- Alcohol consumption ≥ 5 and ≤ 21 units/week
Exclusion
- Smoking
- Family history of alcoholism
- History of medical or surgical events that may significantly affect the study outcome, particularly metabolic or endocrine disorders and gastrointestinal disorders
- Recent blood donation
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
End Date :
June 1 2006
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT00285909
Start Date
March 1 2006
End Date
June 1 2006
Last Update
August 16 2006
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