Status:
COMPLETED
Myocardial Infarction Size Reduction With Atorvastatin
Lead Sponsor:
R&D Cardiologie
Collaborating Sponsors:
UMC Utrecht
Conditions:
Myocardial Infarction
Reperfusion Injury
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine if oral atorvastatin administered just before percutaneous coronary angioplasty for acute myocardial infarction improves early and late heart function as comp...
Detailed Description
Left ventricular remodelling after a myocardial infarction refers to changes in shape and function of the infarcted and uninfarcted myocardium. Remodelling begins minutes after acute myocardial infarc...
Eligibility Criteria
Inclusion
- Consecutive patients (aged \> 18 years) who are to undergo a primary PCI for a first acute ST elevation myocardial infarction will be asked to participate in this study.
Exclusion
- Previous myocardial infarction
- Previous coronary artery bypass grafting (CABG)
- Cardiac rhythm is other than normal sinus rhythm.
- Electrical instability.
- The patient is in Killip class 3 or 4 of heart failure.
- Need for intra aortic balloon counterpulsation therapy
- The patient is unable to hold his/her breath for up to 20 seconds due to age or concomitant illness.
- Implanted electronic devices are present: pacemakers, internal defibrillators, ECG-registration devices, neurostimulators, implanted drug infusion devices, cochlear implants etc.
- Previous vascular surgery: aneurysm clip, carotid artery vascular clamp, aortic clips, or venous umbrella
- Prosthesis (orbital/penile, etc.)
- Spinal/intra-ventricular shunts.
- Swan-Ganz catheter; transdermal delivery systems.
- Metal fragments: eye, head, ear, skin.
- Implants held by magnets.
- Known allergy to MR contrast media
- Prior use of statins
- No PCI performed
- No recanalisation achieved
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2008
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00286312
Start Date
February 1 2006
End Date
February 1 2008
Last Update
May 21 2008
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
St. Antonius Hospital
Nieuwegein, Netherlands, 3435CM
2
University Medical Centre Utrecht
Utrecht, Netherlands