Status:
COMPLETED
Comparison of Two Different Doses of Paracetamol for Post-Operative Pain Relief
Lead Sponsor:
University of Otago
Collaborating Sponsors:
Australian and New Zealand College of Anaesthetists
Conditions:
Adult Patients Scheduled for 3rd Molar Teeth Extractions
Eligibility:
All Genders
18-55 years
Phase:
PHASE4
Brief Summary
Paracetamol is commonly used to reduce pain after operations. Recently anaesthetists have been using bigger doses of paracetamol because it has been suggested that bigger doses will work better. Howev...
Detailed Description
A randomised, crossover dose-effect trial of paracetamol 60 and 90 mg/kg in third molar surgery Background Paracetamol is the most widely used analgesic in New Zealand but relatively little is known ...
Eligibility Criteria
Inclusion
- Eighteen healthy adults, male or female, aged 18 to 50 years scheduled for removal of bilateral, impacted, lower wisdom teeth will be recruited for the trial in the dental school.
Exclusion
- Intolerance to oral medication
- Taking paracetamol and unable to abstain prior to the study
- Hypersensitivity to paracetamol
- Liver or renal failure
- Pregnancy
- Breast feeding
- Poor nutritional status, eating disorder, or Body Mass Index (BMI) less than 16
- Weight greater than 87 kg
- Anticonvulsant medication
- Chronic ethanol abuse
- H/o bleeding disorders
Key Trial Info
Start Date :
May 1 2005
Trial Type :
INTERVENTIONAL
End Date :
October 1 2005
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT00286650
Start Date
May 1 2005
End Date
October 1 2005
Last Update
February 3 2006
Active Locations (1)
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1
School of Dentistry, University of Otago
Dunedin, Otago, New Zealand, 913