Status:
COMPLETED
Reduction of Atrial Fibrillation Study in Patients Undergoing Coronary Artery Bypass Grafting. (RASCABG 1 Study)
Lead Sponsor:
University of Aarhus
Conditions:
Atrial Fibrillation
Coronary Artery Bypass Grafting
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether postoperatively oral treatment with high dosis amiodarone for five days after intravenously admitted bolusinfusion will minimize the risk for developm...
Detailed Description
New-onset atrial fibrillation (AF) after coronary bypass grafting (CABG) is common, with an incidence ranging from 5%-65%. Although postoperative atrial tachyarrhythmia is often regarded as a tempora...
Eligibility Criteria
Inclusion
- enlistment for an elective CABG
- age more than 18 years
- willingness to be randomised
- provision of informed consent
Exclusion
- enlistment for other types of heart surgery
- earlier heart surgery
- resting heart rate below 40 bpm.
- AV-blockage of any degree
- preoperative atrial fibrillation or flutter
- former known atrial fibrillation or flutter lasting more than one month
- hepatic dysfunction (ALAT \> twice the upper normal limit)
- hyperthyroidism
- pregnancy
- breastfeeding
- known adverse reactions to amiodarone
Key Trial Info
Start Date :
January 1 2004
Trial Type :
INTERVENTIONAL
End Date :
August 1 2005
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT00287209
Start Date
January 1 2004
End Date
August 1 2005
Last Update
February 6 2006
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Cardiothoracic and Vascular Surgery & Institute of Clinical Medicine, Skejby Sygehus, Aarhus University Hospital
Aarhus N, Denmark, 8200