Status:
COMPLETED
Effect of Antimalarial Treatment on Gametocyte Carriage in Asymptomatic P. Falciparum
Lead Sponsor:
London School of Hygiene and Tropical Medicine
Collaborating Sponsors:
Medical Research Council Unit, The Gambia
Conditions:
Asymptomatic P.Falciparum Malaria
Eligibility:
All Genders
6+ years
Phase:
PHASE3
Brief Summary
Treatment of uncomplicated P.falciparum malaria with sulfadoxine-pyrimethamine (SP) is followed by a marked increase in the density of gametocytes. To determine whether treatment with SP enhances game...
Detailed Description
Treatment of P. falciparum malaria with sulfadoxine-pyrimethamine (SP) is followed by a sharp rise in the density of gametocytes. Drug-induced release could enhance transmission of resistant parasites...
Eligibility Criteria
Inclusion
- P.falciparum parasitaemia above 20/uL
- Resident in one of the four study villages
Exclusion
- Fever
- Any other sign of clinical malaria
- Pregnancy
- Weight \<5kg
- History of hypersensitivity to any of the study drugs
- Treatment with any of the study drugs in the last 4 weeks
Key Trial Info
Start Date :
May 1 2001
Trial Type :
INTERVENTIONAL
End Date :
December 1 2001
Estimated Enrollment :
360 Patients enrolled
Trial Details
Trial ID
NCT00289250
Start Date
May 1 2001
End Date
December 1 2001
Last Update
March 1 2006
Active Locations (1)
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1
Medical Reseearch Council Laboratories The Gambia
Banjul, The Gambia, POBOX 273