Status:
COMPLETED
Efficacy and Safety Study of Chromium Picolinate + Biotin on Glucose and Cholesterol Control in T2DM
Lead Sponsor:
Nutrition 21, Inc.
Conditions:
Diabetes Mellitus, Type 2
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
To evaluate the effect of the combination of chromium picolinate (600 μg Cr) + biotin (2 mg) versus placebo on glycosylated hemoglobin (HbA1c), lipid profiles (Total-C, HDL-C, LDL-C, TGs, TG/HDL ratio...
Detailed Description
There will be an Initial Pre-Screening Contact, two office visits (Baseline and Final), and two mid-study phone contacts with the subject during the course of the study. Volunteers will take either ch...
Eligibility Criteria
Inclusion
- Diagnosis of type 2 diabetes \> 12 months.
- Male and female between the ages of 18 and 70 years, inclusive.
- HbA1c \> 7.0%.
- Subject must be receiving an anti-hyperglycemic medication. Medication dosage must be stable for at least 60 days prior to entering trial. Insulin usage must be for rescue purposes only. Rescue insulin use may not be more than once per week.
- Subjects with a body mass index (BMI) \>/= 25 and \< 35.
- Subject must be ambulatory.
- Willing to perform self-administered blood glucose monitoring.
- Willing to complete all study related requirements.
- Subject will provide written consent to participate in the trial and this consent must be given voluntarily.
Exclusion
- Diagnosis of type 1 diabetes.
- Hypoglycemic event requiring EMS intervention within 12 months.
- Diabetic Ketoacidosis (DKA) within 12 months.
- Subjects taking any supplement containing chromium picolinate within the last 90 days prior to enrollment.
- Subjects taking a supplement or multivitamin containing any other form of chromium \> 120 mcg/daily within the last 30 days prior to enrollment.
- Creatinine \> 2.0 x ULN; AST or ALT \> 2.0 x ULN; Total Bilirubin \> 1.5 x ULN
- COPD, CHF, Angina, HTN, MI, or any other CVD requiring hospitalization within 12 months.
- History of cerebrovascular accident (CVA), pulmonary embolism (PE), or an unresolved deep vein thrombosis (DVT).
- History of CABG, PTCA, or any other reperfusion therapy within 12 months.
- Seated systolic BP \> 160 mmHg.
- Morbid obesity.
- Any psychiatric or mental health issue that would prevent the subject from completing the study. (e.g. Severe depression, schizophrenia, high suicide risk, bi-polar disorder, dementia, substance abuse, etc,)
- History of any serious immunosuppressive disorder or current immunosuppressive therapy.
- Female subjects who are pregnant or nursing, or are planning on becoming pregnant during the study.
- Any illness or complication factor that, in the opinion of the investigator, would jeopardize the subject's health or well being by participating in the study or would interfere with the subject successfully completing the study.
- Current diagnosis of any uncontrolled metabolic disease that would affect carbohydrate or glucose metabolism other than type 2 diabetes. (e.g. hyper or hypothyroidism). (NOTE: Subject's condition must be stable for \> 12 months with no medication changes within the last 12 months preceding enrollment. Subject's TSH must be within range of normality at the time of enrollment to qualify).
- Current participation in any other clinical research trial for any product or device, or participation in said clinical trials within 30 days prior to enrollment.
Key Trial Info
Start Date :
March 1 2003
Trial Type :
INTERVENTIONAL
End Date :
November 1 2005
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT00289354
Start Date
March 1 2003
End Date
November 1 2005
Last Update
February 9 2006
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