Status:
COMPLETED
Safety and Immunogenicity Study of an Inactivated Influenza Vaccine (Whole Virion, Vero Cell Derived)
Lead Sponsor:
Alachua Government Services, Inc.
Conditions:
Influenza
Eligibility:
All Genders
18-45 years
Phase:
PHASE1
PHASE2
Brief Summary
The objective of this study is to assess the safety and immunogenicity of inactivated influenza vaccine (whole virion, Vero cell derived). Subjects will be randomly assigned to receive a single inject...
Eligibility Criteria
Inclusion
- Male and female subjects who
- are 18 to 45 years of age, inclusive, on the day of screening;
- have an understanding of the study, agree to its provisions, and give written informed consent prior to study entry;
- are clinically healthy (in a physical condition such that the physician would have no reservations vaccinating with an influenza vaccine outside the scope of a clinical study);
- agree to keep a daily record of symptoms;
- if female and capable of bearing children - have a negative urine pregnancy test result at study entry and agree to employ adequate birth control measures for the duration of the study.
Exclusion
- Subjects who
- have received any influenza vaccination for the 2005/2006 influenza season and/or the 2004/2005 influenza season;
- have received any vaccination within 2 weeks prior to vaccination in this study;
- suffer from any kind of immunodeficiency;
- suffer from a disease (e.g. autoimmune disease) or are undergoing a form of treatment (e.g. systemic corticosteroids) that can be expected to influence immune response;
- have a history of inflammatory or degenerative neurological disease (e.g. Guillain Barré, multiple sclerosis);
- have received a blood transfusion or immunoglobulins within 30 days of study entry;
- have donated blood or plasma within 30 days of study entry;
- have a history of any vaccine related contraindicating event (e.g., anaphylaxis, allergy to eggs, allergy to components of the test or comparator vaccine, other known contraindications);
- have a rash, dermatologic condition or tattoos which may interfere with injection site reaction rating;
- have a known or suspected problem with alcohol or drug abuse;
- are unable to lead an independent life as a result of either physical or mental handicap;
- were administered an investigational drug within six weeks prior to study entry;
- are concurrently participating in a clinical study that includes the administration of an investigational product;
- if female, are pregnant or lactating;
- are a member of the team conducting this study or are in a dependent relationship with the study investigator. Dependent relationships include close relatives (i.e., children, partner/spouse, siblings, parents) as well as employees of the investigator.
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
423 Patients enrolled
Trial Details
Trial ID
NCT00289510
Start Date
January 1 2006
Last Update
October 9 2015
Active Locations (3)
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1
Allgemeines Krankenhaus Wien (General Hospital Vienna)
Vienna, Austria, 1090
2
Klinikum Westend, Haus 18
Berlin, Germany, 14050
3
Internistische Gemeinschaftspraxis Dr. Regner & Dr. Schmitt (Group practice for internal medicine)
Mainz, Germany, 55116