Status:
COMPLETED
Artemisinin-Based Combination Therapy: Clinical Trials in Cameroon
Lead Sponsor:
London School of Hygiene and Tropical Medicine
Collaborating Sponsors:
University of Yaounde
Cameroon Baptist Convention Health
Conditions:
Malaria
Eligibility:
All Genders
6-120 years
Phase:
PHASE3
Brief Summary
This proposal aims to evaluate the safety and efficacy of artemisinin-based anti-malaria combination drugs (ACTs) for the treatment of children aged 6-120 months in different locations in Cameroon. Ra...
Detailed Description
* Outpatients will be screened for malaria by blood film examination * Malaria-positive children will be examined by the physician for inclusion or exclusion(see below) * Informed consent will be soug...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- children aged 6-120 months;
- axillary temperature ≥ 37.5°C and/or history of fever within past 24 hours;
- P. falciparum asexual parasitemia between 1000 and 100000/µl;
- ability to attend follow-up visits.
- Exclusion criteria:
- co-infections;
- underlying chronic disease;
- severe malaria as indicated by hyperparasitemia, severe anemia (PCV 15%, Hb 5g/ml), respiratory distress, inability to drink, persistent vomiting in past 24 hours;
- recent history of multiple convulsions;
- jaundice;
- the inability to stand or sit;
- history of allergy to study drugs.
Exclusion
Key Trial Info
Start Date :
July 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2009
Estimated Enrollment :
816 Patients enrolled
Trial Details
Trial ID
NCT00297882
Start Date
July 1 2006
End Date
July 1 2009
Last Update
June 8 2021
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