Status:
COMPLETED
Influence of Treatment With Olanzapine or Ziprasidone on Transcapillary Glucose Transport in Human Skeletal Muscle
Lead Sponsor:
Medical University of Vienna
Conditions:
Healthy Male Volunteers
Eligibility:
MALE
18-55 years
Phase:
PHASE4
Brief Summary
Healthy volunteers will undergo euglycaemic hyperinsulinaemic clamp and microdialysis before and after administration of 10mg olanzapine or 80mg ziprasidone during 10 days.
Detailed Description
Background: The efficacy of atypical antipsychotics, such as olanzapine, clozapine, risperidone, quetiapine and ziprasidone in treating a broad spectrum of symptoms in schizophrenia as well as their ...
Eligibility Criteria
Inclusion
- Age between 18-55
- Healthy male volunteers
- No history of drug or alcohol abuse
- No regular nicotine consumption at time of enrollment
- Physical activity at least twice a week
- Body mass Index between 19-24 kg/m2
- Normal laboratory values
- Normotension (blood pressure less than 140/90)
- No past or present history of psychiatric disorder
- No family history of diabetes or obesity
- Written informed consent
Exclusion
- Use of medication within the last 14 days
- Consumption of alcohol within the last 5 days
- Family history of diabetes or obesity
- Past or present psychiatric disorder
Key Trial Info
Start Date :
April 1 2005
Trial Type :
INTERVENTIONAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00297960
Start Date
April 1 2005
Last Update
October 18 2006
Active Locations (1)
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1
Department of Clinical Pharmacology, Medical University Vienna
Vienna, Austria, 1090