Status:
COMPLETED
Pilot Study on Shear-induced Platelet Aggregation in Acute Coronary Syndromes
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Angina, Unstable
Eligibility:
All Genders
18-85 years
Brief Summary
The purpose of this study is to determine whether shear-induced platelet aggregation is able to discriminate first acute coronary syndrome (ACS) from recurrent ACS
Detailed Description
Predictive factors of recurrence of ACS are not well determined. Platelet aggregation and leucocyte activation seem to be involved in the pathogenesis. The aim of our study is to compare SIPA, platele...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- over 18 years old. informed consent signed. acute coronary syndrome not associated with co-morbidity as bleeding diathesis or myocardial infarction during the procedure.
- clinical symptoms in agreement with myocardial infarction during the preceding 24 hours.
- CK OR troponin elevation and one or more of the following criteria: ECG modifications transient ST elevation\>1 mm. new inversion of ST \<1 mm on 2 contiguous derivations.
- Exclusion criteria:
- Acute coronary syndrome with persistent ST elevation. Angioplasty in emergency before blood sampling. Inflammatory disease or cancer. Coagulation abnormalities. Antiphospholipid syndrome. Treatment by vitamin K antagonist. Severe disease with life expectancy lower than 2 years. One-year follow up impossible.
Exclusion
Key Trial Info
Start Date :
June 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2010
Estimated Enrollment :
97 Patients enrolled
Trial Details
Trial ID
NCT00299143
Start Date
June 1 2005
End Date
June 1 2010
Last Update
December 29 2011
Active Locations (1)
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1
Bichat Hospital
Paris, France, 75018