Status:
COMPLETED
Effect of Nasal Continuous Positive Airway Pressure (CPAP) Blood Pressure and Vascular Endothelial Growth Factor in Obstructive Sleep Apnea Syndrome
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Obstructive Sleep Apnea
Eligibility:
All Genders
20-80 years
Phase:
NA
Brief Summary
Sleep-disordered breathing (SDB) briefly means cessation of breathing during sleep at least 5 times per hour. SDB is a common disorder affecting 9 to 24% of the middle-aged and overall 4% of the middl...
Detailed Description
Subjects and Methods: We propose to carry out a prospective, randomized sham placebo-controlled parallel study on 140 consecutive patients newly diagnosed with OSA, as defined by overnight sleep stud...
Eligibility Criteria
Inclusion
- Age 20 to 80 yrs
- Apnea hypopnea index (AHI) \> 10/hr on Polysomnograph (PSG) with symptoms of obstructive sleep apnea (OSA) as described previously
- Epworth Sleepiness Scale (ESS) \>10
- Patients with hypertension will still be eligible to enter and continue the study as long as there is no alteration of anti-hypertensive medications during the study period
Exclusion
- Patients having problems staying awake during driving, shift work
- Recent myocardial infarction
- Unstable angina
- Underlying malignancy
Key Trial Info
Start Date :
January 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 6 2019
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT00300872
Start Date
January 1 2005
End Date
August 6 2019
Last Update
January 27 2021
Active Locations (1)
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1
The Chinese University of Hong Kong
Shatin, New Territories, Hong Kong