Status:
COMPLETED
Treatment of Persistent Wheezing in Infants and Children
Lead Sponsor:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Asthma
Respiratory Sounds
Eligibility:
All Genders
Up to 36 years
Phase:
NA
Brief Summary
Wheezing is a high-pitched whistling sound that is produced when air flows through narrowed lung airways. It is a common symptom of asthma. Persistent wheezing is commonly treated with bronchodilators...
Detailed Description
Asthma prevalence has steadily increased in the United States since the early 1980s, with infants and young children showing the largest increase. Some young children experience wheezing, but it is no...
Eligibility Criteria
Inclusion
- Moderate to severe persistent wheezing, as defined by the National Asthma Education and Prevention Program Expert Panel Report 2
- No signs of upper or lower respiratory tract infection for at least two weeks prior to study entry
Exclusion
- Received therapy with inhaled corticosteroids in the month prior to study entry
- History of seizures or other neurologic disorders
- Hypoxemia requiring supplemental oxygen to maintain oxygen saturation above 90%
- Sepsis
- Underwent a tracheostomy
- Heart disease
- Suspected or documented pulmonary hypertension
- Currently undergoing assisted ventilation
- Born at less than 36 weeks gestation
Key Trial Info
Start Date :
September 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2007
Estimated Enrollment :
54 Patients enrolled
Trial Details
Trial ID
NCT00301171
Start Date
September 1 2003
End Date
August 1 2007
Last Update
July 29 2016
Active Locations (1)
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1
University of Michigan
Ann Arbor, Michigan, United States, 48109