Status:
COMPLETED
Effect of Complementary Intracoronary Streptokinase Administration Immediately After Primary Percutaneous Coronary Intervention on Microvascular Perfusion and Late Term Infarct Size in Patients With Acute Myocardial Infarction
Lead Sponsor:
Istanbul University
Conditions:
Acute Myocardial Infarction
Eligibility:
All Genders
20-75 years
Phase:
PHASE4
Brief Summary
The investigators hypothesized that complementary intracoronary streptokinase administration to primary percutaneous intervention in patients with acute myocardial infarction may provide further impro...
Detailed Description
Mechanical reperfusion for acute myocardial infarction (AMI) targets optimal revascularization of the epicardial artery but also aims at improved myocardial salvage. The goal of reperfusion therapies ...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Continuous chest pain that lasted \> 30 minutes within the preceding 12 hours
- ST-segment elevation of at least 1 mm in 2 contiguous leads on the 12 leads ECG
- Infarct related artery (IRA) occlusion (TIMI grade 0) at the angiography
- Angiographically detected culprit coronary artery lesion deemed suitable for PCI
- Exclusion Criteria:
- Contraindications to streptokinase, tirofiban, aspirin, clopidogrel, or heparin
- Culprit lesion in saphenous vein graft
- TIMI grade II-III flow in IRA
- Additional epicardial stenosis in the IRA distal to stented segment (significant or insignificant)
- Presence of left bundle branch block
- History of prior MI
- Mechanical ventilation or inotropic support
Exclusion
Key Trial Info
Start Date :
October 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2008
Estimated Enrollment :
95 Patients enrolled
Trial Details
Trial ID
NCT00302419
Start Date
October 1 2004
End Date
February 1 2008
Last Update
August 1 2008
Active Locations (1)
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1
Istanbul University, Istanbul School of Medicine, Department of Cardiology
Istanbul, Turkey (Türkiye), 34290