Status:
COMPLETED
Humoral Determinants of Immunity to Pneumococcal Infection
Lead Sponsor:
VA Office of Research and Development
Collaborating Sponsors:
Michael E. DeBakey VA Medical Center
Conditions:
Pneumonia
Pneumococcal Infections
Eligibility:
All Genders
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine whether there are differences in the level of antibody to capsular polysaccharides of S. pneumoniae or the physiological activity of such antibody after vacci...
Detailed Description
Streptococcus pneumoniae (pneumococcus) is the most common cause of pneumonia leading to hospitalization of adults. Resistance to infection is generally thought to be highly associated with antibody t...
Eligibility Criteria
Inclusion
- Diagnosis of pneumococcal pneumonia
- Age matched controls who have not had pneumococcal pneumonia
- Patients enrolled must be veterans
Exclusion
- Patients who do not have the diagnosis of pneumococcal pneumonia based on a clinical syndrome that is consistent with pneumonia and the finding of pneumococcus in blood or sputum or any other sterile site will be excluded
- Women of child-bearing age will be excluded
- Patients who have had a prior reaction to pneumococcal vaccine that they describe as 'severe' will be excluded
Key Trial Info
Start Date :
January 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2012
Estimated Enrollment :
114 Patients enrolled
Trial Details
Trial ID
NCT00304382
Start Date
January 1 2003
End Date
June 1 2012
Last Update
September 5 2017
Active Locations (1)
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1
Michael E. DeBakey VA Medical Center, Houston, TX
Houston, Texas, United States, 77030