Status:
COMPLETED
Effects of Caffeinated and Decaffeinated Coffee on Body Weight and Glucose Tolerance
Lead Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsors:
Harvard School of Public Health (HSPH)
Beth Israel Deaconess Medical Center
Conditions:
Overweight
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Habitual consumption of coffee may have substantial beneficial effects on glucose metabolism according to recent findings of epidemiological studies in the U.S., Europe, and Japan. However, data from ...
Detailed Description
Habitual consumption of coffee may have substantial beneficial effects on glucose metabolism according to recent findings of epidemiological studies in the U.S., Europe, and Japan. However, data from ...
Eligibility Criteria
Inclusion
- Aged at least 18 years with an ability and willingness to give written informed consent.
- Body mass index 25-35 kg/m2
- Users of at least 2 cups of caffeinated coffee per day who are willing to be randomized to any of the interventions.
- Non-smoking
Exclusion
- Any condition/illness that may affect the study outcomes or would make participation potentially harmful such as pregnancy or breastfeeding, diabetes mellitus, heart disease, stroke, hypertension, malabsorption syndromes, Gastroesophageal reflux disease GERD, a history of ulcer, according to a detailed medical history.
- Abnormal hepatic function (liver function test \> twice the normal range), abnormal renal function (creatinine \> 1.1 mg/dl), fasting plasma glucose in the diabetic range (\>/= 126 mg/dl), or blood pressure \> 140/90 mmHg.
- Present alcoholism or drug abuse or use of medications that could interfere with the treatment including bronchodilators, quinolone antibiotics, monoamine oxidase inhibitors, anxiolytics, ranitidine, corticosteroids, growth hormone, antihypertensives.
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2008
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT00305097
Start Date
May 1 2006
End Date
September 1 2008
Last Update
March 6 2018
Active Locations (1)
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1
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215