Status:
WITHDRAWN
The Effects of Dietary Phosphate Intake on Calciotropic Hormones and FGF23.
Lead Sponsor:
University of California, San Francisco
Collaborating Sponsors:
National Institutes of Health (NIH)
Conditions:
Healthy
Kidney Failure, Chronic
Eligibility:
All Genders
21-65 years
Phase:
NA
Brief Summary
The purpose of this study is to determine the effects of different amounts of phosphorus in the diet on hormones that control phosphorus and bone health both in people who are healthy and in ones who ...
Detailed Description
Chronic kidney disease affects 11% of the US population; over half of those affected have skeletal manifestations of their renal disease. Renal osteodystrophy is a complex disease, in which multiple m...
Eligibility Criteria
Inclusion
- HEALTHY SUBJECTS:
- Men 21-65 years of age;
- Premenopausal women over 21 years of age taking oral contraceptives;
- Postmenopausal women less than 65 years of age;
- CHRONIC KIDNEY DISEASE SUBJECTS:
- Men 21-65 years of age;
- Premenopausal women over 21 years of age taking oral contraceptives;
- Postmenopausal women less than 65 years of age;
- Creatinine clearance between 30 and 59 ml/min/1.73 m2 as calculated using the equation derived from the Modification of Diet in Renal Disease (MDRD) study.
Exclusion
- Medications affecting bone metabolism;
- Abnormal liver or GI function;
- Extreme electrolyte abnormalities;
- BMI \>30 kg/m2.
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2009
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00305279
Start Date
February 1 2006
End Date
December 1 2009
Last Update
October 10 2013
Active Locations (1)
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1
University of California
San Francisco, California, United States, 94143