Status:
COMPLETED
Synbiotic Treatment in Crohn's Disease Patients
Lead Sponsor:
University of Dundee
Conditions:
Crohn's Disease
Eligibility:
All Genders
18-79 years
Phase:
NA
Brief Summary
The purpose of this study is to determine whether administration of a synbiotic, comprised on inulin and a bifidobacterial probiotic will colonise the gut wall and down-regulate TNF-alpha and other pr...
Detailed Description
Crohn's disease is one of the two main forms of idiopathic inflammatory bowel disease. The Th1-mediated inflammatory response in Crohn's disease is characterised by increased IL-18 and INF-gamma and e...
Eligibility Criteria
Inclusion
- Crohn's disease of large bowel (+/- small bowel disease)
- 18-79 years old
- stable doses of medications
- CDAI \>150, \<450
Exclusion
- short gut syndrome
- pregnancy
- lactation
- antibiotic therapy in last 3 months
- probiotic therapy in last 1 month
- \<18, \>79 years old
- CDAI \<150 or \>450
- indeterminate colitis, ulcerative colitis
- alterations to medications in last 3 months
Key Trial Info
Start Date :
June 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2008
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT00305409
Start Date
June 1 2006
End Date
December 1 2008
Last Update
February 11 2009
Active Locations (2)
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1
Dundee University, Dept of Pathology and Neuroscience
Dundee, Angus, United Kingdom, DD1 9SY
2
Ninewells Hospital and Medical School
Dundee, Tayside, United Kingdom, DD1 9SY