Status:
COMPLETED
Study Comparing Outcomes for Patients With Treatment Resistant Depression Who Receive VNS Therapy at Different Doses
Lead Sponsor:
Cyberonics, Inc.
Conditions:
Depression
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
This is a postmarket medical device study. The objective of this study is to compare the safety and effectiveness of Vagus Nerve Stimulation (VNS) Therapy administered at different amounts of electric...
Detailed Description
This is a postmarket medical device study. This study will examine treatment outcomes for patients with TRD who are randomized to VNS Therapy administered at different amounts of electrical charge. Th...
Eligibility Criteria
Inclusion
- Patient has a diagnosis of chronic or recurrent depression and is currently experiencing a major depressive episode.
- Patient has not had an adequate response to four or more adequate antidepressant treatments from at least two different antidepressant treatment categories.
- Patient has (in the investigator's judgment) sufficient impairment from his/her depression and/or depression treatment that the potential benefits/risks of VNS Therapy are warranted.
- Patient must currently be receiving at least one antidepressant treatment; the patient must be receiving all current antidepressant treatments in a stable regimen.
- If the patient has a current diagnosis of bipolar disorder, the patient must be receiving a mood stabilizer.
- Patient must be 18 years of age or older and of legal age of consent.
- Patient must be able to complete the evaluations specified in the study procedures flow chart.
- Patient must provide written informed consent and Health Insurance Portability and Accountability Act (HIPAA) authorization.
Exclusion
- Patient has had a bilateral or left cervical vagotomy.
- Patient currently uses, or is expected to use during the study, short-wave diathermy, microwave diathermy, or therapeutic ultrasound diathermy.
- A VNS Therapy System implant would pose an unacceptable surgical or medical risk for the patient.
- Patient is expected to require full body magnetic resonance imaging during the clinical study.
- Patient is acutely suicidal.
- Patient has a history of schizophrenia, schizoaffective disorder, or other psychotic disorder or a current major depressive episode that includes psychotic features (commonly referred to as psychotic depression).
- Patient has a history of rapid cycling bipolar disorder or a current diagnosis of bipolar disorder mixed phase.
- Patient has a history of borderline personality disorder.
- Patient has a history of drug or alcohol dependence within the 12 months prior to the baseline visit or currently takes a narcotic drug five or more days per week.
- Patient is currently enrolled in another investigational study.
- Patient has had a prior VNS Therapy System implant.
- Note: Some IRBs may require additional conditions for enrollment.
Key Trial Info
Start Date :
January 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2010
Estimated Enrollment :
331 Patients enrolled
Trial Details
Trial ID
NCT00305565
Start Date
January 1 2006
End Date
February 1 2010
Last Update
January 7 2014
Active Locations (26)
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1
University of Arizona
Tucson, Arizona, United States, 85724
2
Sutter Institute for Medical Research
Sacramento, California, United States, 95816
3
Northwest Behavioral Research Center
Marietta, Georgia, United States, 30060
4
Evanston Northwestern Hospital
Evanston, Illinois, United States, 60201