Status:
COMPLETED
Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke
Lead Sponsor:
National Institute on Drug Abuse (NIDA)
Conditions:
Tobacco-Use Disorder
Schizophrenia
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
Many individuals with schizophrenia smoke cigarettes. Individuals in the schizophrenic population often find it difficult to quit smoking. The purpose of this trial is to determine the safety and effe...
Detailed Description
Schizophrenia affects 1 % of the population. Among individuals with schizophrenia, between 74 and 92 % smoke cigarettes regularly. Heavy smoking represents a significant and neglected public health pr...
Eligibility Criteria
Inclusion
- Meets DSM-IV criteria for schizophrenia or schizoaffective disorder
- Receiving a stable dose of antipsychotic medication for at least 1 month prior to study entry
- Smokes at least 10 cigarettes per day
- Wishes to stop smoking
- Attended last three scheduled clinic visits, prior to study entry
Exclusion
- Significant medical or neurologic illness
- History of severe head injury with loss of consciousness
- Treated with monoamine oxidase inhibitors or carbamazepine in the 14 days prior to study entry
- Taking clozapine at doses greater than 500 mg/d without an anticonvulsant
- Currently undergoing an acute exacerbation of psychotic symptoms
- Current or history of bulimia or anorexia
- Current excessive water intake
- Recent history of mania
- Known allergy or hypersensitivity to bupropion
- Current substance abuse other than tobacco, nicotine replacement treatment, or smokeless tobacco
- Currently receiving treatment with bupropion
- Pregnant or breastfeeding
Key Trial Info
Start Date :
August 1 1998
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2004
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT00307203
Start Date
August 1 1998
End Date
February 1 2004
Last Update
January 11 2017
Active Locations (1)
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1
Freedom Trail Clinic
Boston, Massachusetts, United States, 02114