Status:
COMPLETED
Physiology of Weakness in Movement Disorders
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Movement Disorders
Eligibility:
All Genders
18-80 years
Brief Summary
This study will compare electroencephalograph (EEG) recordings in healthy volunteers and in people with movement disorders to examine brain activity associated with the weakness. EEG records the elect...
Detailed Description
Objective Give way weakness is a symptom often associated with psychogenic etiology, but its neurophysiological basis is poorly understood. Our objective in this study is to identify the cerebral mec...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Both patients and healthy volunteers will be between age 18 and 80.
- Patients will be evaluated in the Human Motor Control Clinic at NINDS.
- The definite diagnosis of the disease may not be completely established at the time of recording.
- Patients have clear and reproducible symptoms of give way weakness of either upper or lower extremities.
- Patients have to be able to resist against the examiner for at least two seconds before giving way.
- Healthy volunteers are right handed adults without history of neurological disease or severe head trauma.
- EXCLUSION CRITERIA:
- Subjects (patients or volunteers) who cannot understand the instructions and consent forms of the protocol will be excluded.
- Subjects who cannot follow the instruction during the entire recording for whatever reason will be excluded.
- Patients with a documented organic central nervous system lesion may be excluded from the study. This will be discussed in detail for each individual subject at the Human Motor Control Clinic.
Exclusion
Key Trial Info
Start Date :
March 23 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 25 2011
Estimated Enrollment :
6 Patients enrolled
Trial Details
Trial ID
NCT00307346
Start Date
March 23 2006
End Date
January 25 2011
Last Update
July 2 2017
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892