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Status:

COMPLETED

Endothelial Progenitor Cells and Nitric Oxide in Cardiac Rehabilitation Program Participants

Lead Sponsor:

National Heart, Lung, and Blood Institute (NHLBI)

Conditions:

Coronary Artery Disease (CAD)

Eligibility:

All Genders

21+ years

Brief Summary

This study will measure blood levels of endothelial progenitor cells (EPCs) and nitric oxide (NO) in patients with coronary artery disease (CAD) who are participating in a 3-month cardiac rehabilitati...

Detailed Description

Exercise training has long been recommended as a means of improving effort tolerance and reducing morbidity and mortality in patients with coronary artery disease (CAD). One mechanism of benefit may b...

Eligibility Criteria

Inclusion

  • INCLUSION CRITERIA:
  • Adults older than 21 years.
  • Coronary artery disease established by angiography.
  • At least two months interval since myocardial infarction or coronary artery bypass surgery.
  • At least one month interval since percutaneous coronary intervention or congestive heart failure symptoms.
  • No medical condition that might prohibit safe participation in cardiac rehabilitation.
  • Subject understands protocol and provides written, informed consent in addition to willingness to comply with specified follow-up evaluations.
  • EXCLUSION CRITERIA:
  • Significant structural heart disease (e.g. hypertrophic or dilated cardiomyopathy, valvular heart disease) as determined by echocardiography.
  • Angina pectoris that is prolonged in duration (greater than 20 minutes), or does not respond to nitroglycerin (2 tablets) within 2 weeks of referral to the program.
  • Subjects physically unable to perform cardiac rehabilitation protocol due to neurologic or orthopedic conditions.
  • Women of childbearing age unless recent pregnancy test is negative.
  • Lactating women.
  • Implantable cardioverter-defibrillator (ICD)

Exclusion

    Key Trial Info

    Start Date :

    March 23 2006

    Trial Type :

    OBSERVATIONAL

    End Date :

    Estimated Enrollment :

    55 Patients enrolled

    Trial Details

    Trial ID

    NCT00308633

    Start Date

    March 23 2006

    Last Update

    July 2 2017

    Active Locations (2)

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    Page 1 of 1 (2 locations)

    1

    Suburban Hospital

    Bethesda, Maryland, United States, 20814

    2

    National Institutes of Health Clinical Center, 9000 Rockville Pike

    Bethesda, Maryland, United States, 20892