Status:
COMPLETED
Transcranial Magnetic Stimulation for "Voices"
Lead Sponsor:
Yale University
Collaborating Sponsors:
National Institute of Mental Health (NIMH)
Conditions:
Schizophrenia
Hallucinations
Eligibility:
All Genders
18-55 years
Phase:
PHASE2
Brief Summary
This study will determine the efficacy of MRI-guided transcranial magnetic stimulation (TMS)in reducing "voices" and other symptoms experienced by people with schizophrenia and schizoaffective disorde...
Detailed Description
Schizophrenia is a severely disabling brain disorder that affects about 1% of the United States population. Approximately 50 to 80% of people with schizophrenia experience "voices," also known as audi...
Eligibility Criteria
Inclusion
- Auditory hallucinations that occur at least five times per day, on average
- Diagnosis of schizophrenia or schizoaffective disorder
Exclusion
- Pregnant
- History of seizure that is not drug-induced or secondary to alcohol withdrawal
- Drug or alcohol abuse within 6 weeks of study entry (prior history of drug or alcohol abuse is not an exclusion)
- Changes in antipsychotic drug dosages within 4 weeks of study entry (patients do not need to be on antipsychotic medication to be included)
- Current significant untreated or unstable medical illness (e.g., poorly controlled diabetes mellitus, severe hypertension, unstable cardiac arrhythmia)
- Inability to understand the nature of the study due to severe psychotic disorganization, mental retardation, etc.
- Significant neurological condition (e.g., traumatic brain injury, multiple sclerosis)
- Factors that would preclude an MRI scan (e.g., severe obesity, claustrophobia, certain surgical implants with metallic components, metal shavings in the eye acquired while working as machinist)
- Cardiac pacemaker
Key Trial Info
Start Date :
February 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2012
Estimated Enrollment :
85 Patients enrolled
Trial Details
Trial ID
NCT00308997
Start Date
February 1 2006
End Date
April 1 2012
Last Update
April 2 2020
Active Locations (1)
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1
Yale Psychiatric Research
New Haven, Connecticut, United States, 06519