Status:
COMPLETED
Study of Sildenafil in Advanced Heart Failure.
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Congestive Heart Failure
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
Despite advances in medical therapy for patients with heart failure, one-third of patients remain limited by fatigue and shortness of breath. Our previous study concluded that one dose of sildenafil ...
Detailed Description
This study will compare two groups of patients. One group will receive sildenafil and the other group will receive a placebo (a pill which looks like sildenafil, but contains no medication). Patients...
Eligibility Criteria
Inclusion
- Age \>18 years Ejection fraction \<40% Heart failure limited by fatigue and shortness of breath Pulmonary artery hypertension
Exclusion
- Patients taking the following medications: nitroglycerine pill/patch/paste, isordil, Imdur, antifungal agents and certain antidepressants.
- Patients with a history of optic neuropathy or unexplained visual impairment. Patients with anemia.
- \-
Key Trial Info
Start Date :
May 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2006
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00309790
Start Date
May 1 2003
End Date
March 1 2006
Last Update
August 11 2009
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