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Status:

COMPLETED

Etanercept in Treating Young Patients With Idiopathic Pneumonia Syndrome After Undergoing a Donor Stem Cell Transplant

Lead Sponsor:

Children's Oncology Group

Collaborating Sponsors:

National Cancer Institute (NCI)

Conditions:

Accelerated Phase Chronic Myelogenous Leukemia

Blastic Phase Chronic Myelogenous Leukemia

Eligibility:

All Genders

1-17 years

Phase:

PHASE2

Brief Summary

This phase II trial is studying how well etanercept works in treating young patients with idiopathic pneumonia syndrome after undergoing a donor stem cell transplant. Etanercept may be effective in tr...

Detailed Description

PRIMARY OBJECTIVES: I. Determine the response rate, defined as survival and complete discontinuation of supplemental oxygen at day 28, in pediatric patients with acute noninfectious pulmonary dysfunc...

Eligibility Criteria

Inclusion

  • Inclusion Criteria:
  • Diagnosis of acute, noninfectious idiopathic pulmonary dysfunction (IPS) as defined by the following:
  • Evidence of diffuse lung injury occurring within the first several months after hematopoietic stem cell transplantation for which an infectious etiology is not identified. To meet the criteria for IPS there must be:
  • Evidence of widespread alveolar injury
  • Diffuse multi-lobar infiltrates on chest x-ray or CT scan
  • Evidence for abnormal respiratory physiology based upon 1 of the following:
  • Room air oxygen saturation \< 93%
  • Supplemental oxygen required to maintain an oxygen saturation ≥ 93%
  • Absence of active lower respiratory tract infection, defined as Bronchoalveolar lavage (BAL)-negative for infection based on one of the following:
  • Gram stain, fungal stain, acid-fast bacilli stain
  • Bacterial culture (a quantitative culture ≥ 10\^4 colony-forming units/mL is considered positive)
  • Fungal culture
  • Mycobacterial culture
  • Viral culture (respiratory syncytial virus \[RSV\], parainfluenza, adenovirus, influenza A and B, and cytomegalovirus \[CMV\])
  • If direct fluorescent antibody (DFA) screening is performed on BAL, it must be negative for all viruses listed above
  • Pneumocystis carinii pneumonia by polymerase chain reaction (PCR), DFA stain, or cytology
  • Evidence of bilateral pulmonary infiltrates (on chest radiograph)
  • Patients may have diffuse alveolar hemorrhage (DAH) or peri-engraftment respiratory distress syndrome (PERDS)
  • Presence of "mixed oral flora," "rare Candida species," or the presence of a Penicillium species reported on BAL fluid analysis allowed
  • A radiographic finding of pulmonary edema does not exclude the diagnosis of IPS, provided the other criteria have been met and provided the treating physician concludes by clinical (or echocardiographic) criteria that the pulmonary edema is not secondary to cardiac dysfunction or iatrogenic fluid overload
  • Patients must require supplemental oxygen
  • Must have undergone an allogeneic bone marrow, cord blood, or peripheral blood stem cell transplantation within the past 120 days
  • There are no restrictions based upon underlying disease, donor source, the degree of HLA match, the intensity of the pre-transplant conditioning regimen, or the use of a prior donor leukocyte infusion
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective contraception
  • No documented invasive fungal or systemic viral infection within the past 14 days
  • Patients with asymptomatic viruria allowed
  • No signs of CMV reactivation (by CMV, PCR, antigenemia, or shell vial culture) within the past 14 days
  • No sepsis syndrome or hypotension that requires inotropic support (except dopamine \< 5mcg/kg/minute)
  • No documented bacteremia within the past 48 hours
  • Persistent fever allowed
  • No evidence of cardiac failure by clinical or echocardiographic findings
  • No known hypersensitivity to etanercept
  • No known history of tuberculosis (Tb) or prior Tb exposure
  • No prior chronic hepatitis B or hepatitis C infection
  • Concurrent treatment for acute or chronic GVHD allowed
  • More than 14 days since prior etanercept
  • More than 7 days since prior investigational drug trials (phase I, II, or III) for the treatment of acute graft-versus-host disease (GVHD)
  • Not on mechanical ventilation for \> 48 continuous hours prior to study entry
  • Must not be receiving \> 2 mg/kg/day of methylprednisolone or corticosteroid equivalent within 24 hours of study entry
  • Concurrent continuous veno-venous hemofiltration or hemodialysis allowed

Exclusion

    Key Trial Info

    Start Date :

    April 1 2006

    Trial Type :

    INTERVENTIONAL

    Allocation :

    ACTUAL

    End Date :

    September 1 2011

    Estimated Enrollment :

    39 Patients enrolled

    Trial Details

    Trial ID

    NCT00309907

    Start Date

    April 1 2006

    End Date

    September 1 2011

    Last Update

    September 29 2017

    Active Locations (26)

    Enter a location and click search to find clinical trials sorted by distance.

    Page 1 of 7 (26 locations)

    1

    University of Alabama at Birmingham

    Birmingham, Alabama, United States, 35294

    2

    Children's Oncology Group

    Arcadia, California, United States, 91006-3776

    3

    Loma Linda University Medical Center

    Loma Linda, California, United States, 92354

    4

    Children's Hospital Colorado

    Aurora, Colorado, United States, 80045