Status:
COMPLETED
fMRI Studies of Task Specificity in Focal Hand Dystonia
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Focal Dystonia
Eligibility:
All Genders
18-65 years
Brief Summary
This study will examine how the brain makes involuntary spasms and contractions in patients with focal hand dystonia (FHD). Patients with dystonia have muscle spasms that cause uncontrolled twisting a...
Detailed Description
Objective: Writer's cramp, a form of focal hand dystonia, is the most frequently observed task specific dystonia. Symptoms of writer's cramp often appear as soon as the pen is picked up, or after a f...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Focal Dystonia Subjects must be:
- Right hand dominant
- Between 18 and 65 years old
- Diagnosed with mild, simple focal hand dystonia. For this study mild, simple focal hand dystonia suggests that the patient does not present symptoms when performing tasks other than writing. Additionally, the patient should be able to write for 20 seconds consecutively
- Willing to abstain from alcohol 48 hours prior to the study
- Volunteers must be:
- Healthy right-handed dominant individuals
- Between 18 and 65 years old
- Willing to abstain from alcohol 48 hours prior to the study
- EXCLUSION CRITERIA:
- Subjects with implanted devices such as pacemakers, medication pumps or defibrillators, metal in the cranium except mouth, intracardiac lines, history of shrapnel injury or any other condition/device that may be contraindicated or prevent the acquisition of MRI
- Subjects with any finding on the MRI safety questionnaire which prevents them from safely undergoing an MRI scan
- Subjects who are pregnant.
- Subjects with claustrophobia or other restrictions which prevent them from undergoing a scan in a confined space for up to 60 minutes
- Subjects with any visual, motor, or hearing difficulties
- Subjects with severe focal hand dystonia i.e., subjects who experience dystonic spasms in tasks other than/in addition to writing
- Subjects with mirror dystonia
- Subjects without the capacity to give consent
- Subjects with any history of a severe medical condition, such as cardiovascular disease, which will prevent them from lying flat for up to 60 minutes.
- Subjects with any history of brain tumor, stroke, head trauma or vascular malformation as obtained by history or from imaging studies.
- Subjects who have had recent (within 3 months) Botulinum Toxin (Botox) injections.
- Subjects who are on anti-parkinsonian drugs
Exclusion
Key Trial Info
Start Date :
March 30 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 13 2012
Estimated Enrollment :
51 Patients enrolled
Trial Details
Trial ID
NCT00310414
Start Date
March 30 2006
End Date
March 13 2012
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892