Status:
COMPLETED
A Stepwise Strategy Utilizing Buprenorphine and Methadone
Lead Sponsor:
Karolinska University Hospital
Collaborating Sponsors:
Swedish National Drug Policy Coordinator
Region Stockholm
Conditions:
Heroin Dependence
Eligibility:
All Genders
20+ years
Phase:
PHASE4
Brief Summary
The objective of this study is to compare optimally given methadone maintenance treatment (MMT) for heroin dependence with a novel, sequential strategy, where patients are offered buprenorphine as fir...
Detailed Description
The objective of this study is to compare optimally given methadone maintenance treatment (MMT) for heroin dependence with a novel, sequential strategy (STEP), where patients are offered buprenorphine...
Eligibility Criteria
Inclusion
- Heroin dependence according to DSM IV \> 1year
- Age \> 20 years
- Acceptance of the stated treatment principles.
Exclusion
- Severe psychiatric illness such as dementia or psychosis compromising the patient's ability to provide informed consent
- Other clinically significant psychiatric illness unless stable under treatment
- Severe medical condition such as advanced lung disease, unstable cardiovascular disease, severe liver disease
- Other clinically significant medical condition unless stable under treatment
- Treatment with anti-seizure drugs or disulfiram
- Pregnancy or intent to become pregnant within the next year
- Ongoing nursing
- Patients involuntarily discharged from a methadone or buprenorphine maintenance program within the last 3 months not eligible.
Key Trial Info
Start Date :
August 1 2005
Trial Type :
INTERVENTIONAL
End Date :
March 1 2006
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT00310934
Start Date
August 1 2005
End Date
March 1 2006
Last Update
October 24 2006
Active Locations (1)
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1
Dept of Clinical Neuroscience, Karolinska Inst
Stockholm, Sweden, 14176