Status:
COMPLETED
The Effect of Dihydralazine on Kidney Function and Hormones in Healthy Individuals
Lead Sponsor:
Regional Hospital Holstebro
Conditions:
Healthy
Eligibility:
MALE
18-40 years
Phase:
PHASE4
Brief Summary
We, the investigators at Holstebro Hospital, want to test the hypothesis that dihydralazine leads to the activation of the sympathetic nervous system in healthy individuals.
Eligibility Criteria
Inclusion
- Men
- Ages 18 to 40 years.
- Body mass index less than or equal to 30 kg/m2
Exclusion
- History or clinical signs of heart, lung, kidney, or endocrine organ disease.
- Abnormal biochemical screening of the blood regarding: B-hemoglobin, P-sodium, P-potassium, P-creatinine, P-albumin, P-bilirubin, P-alanine aminotransferase, P-alkaline phosphatase, P-cholesterol, and B-glucose.
- Abnormal screening of the urine regarding: albumin and glucose
- Malignant disease.
- Known arterial hypertension or measured 24 hour blood pressure above 135 mmHg systolic or 85 mmHg diastolic.
- Alcohol abuse.
- Smoking.
- Drug use or abuse.
- Known intolerance or allergy to dihydralazine
- Blood donation within 1 month of the start of the study.
Key Trial Info
Start Date :
April 1 2006
Trial Type :
INTERVENTIONAL
End Date :
November 1 2007
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT00311974
Start Date
April 1 2006
End Date
November 1 2007
Last Update
February 18 2010
Active Locations (1)
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1
Department of Medical Research, Holstebro Hospital
Holstebro, Denmark, 7500