Status:
WITHDRAWN
Amblyopia and Neurovascular Coupling in the Retina of Humans
Lead Sponsor:
Medical University of Vienna
Conditions:
Amblyopia
Regional Blood Flow
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The visual disorder of amblyopia affects 2% to 3% of the population. Amblyopia is a developmental condition that is characterized by reduced vision of the eye due to the presence of a sensory impedime...
Eligibility Criteria
Inclusion
- Inclusion criteria for healthy subjects:
- Women and men, aged between 18 and 60 years
- Matched with regard to age, sex and smoking status
- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
- Normal ophthalmic findings, ametropia of less than 3.0 dpt
- Inclusion criteria for patients with amblyopia as a result of anisometropia or strabismus:
- Normal ophthalmic findings except amblyopia on one eye resulting from anisometropia or strabismus with a visual acuity between log Mar 0.3 and 0.7 (Snellen 0.2-0.5) with best correction on the amblyopic eye and 0.1 (Snellen 0.9) or better on the contralateral eye
- Anisometropia of more 3 dpt (patients with anisometropia)
- Women and men, aged between 18 and 60 years
- Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
Exclusion
- Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
- pregnancy
- Treatment in the previous 3 weeks with any drug
- Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- Blood donation during the previous 3 weeks
Key Trial Info
Start Date :
July 1 2003
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00312390
Start Date
July 1 2003
Last Update
December 8 2014
Active Locations (1)
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1
Department of Clinical Pharmacology
Vienna, Austria, 1090