Status:
COMPLETED
Polymorphisms in the Human Matrix Metalloproteinase Genes MMP1, MMP3, and MMP9: Genetic Risk Factors of Primary Open Angle Glaucoma?
Lead Sponsor:
Medical University of Vienna
Conditions:
Glaucoma
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
Matrix metalloproteinases (MMPs) fulfill diverse important molecular functions and play pivotal roles in development, tissue morphogenesis, repair, aging, and inflammatory processes. MMPs are also imp...
Eligibility Criteria
Inclusion
- Men and women older than 39 years
- Primary open angle glaucoma as evidenced from characteristic visual field loss and optic disc cupping (POAG group)
- Healthy subjects matched by age, sex and ethnicity to the POAG patients group (control group)
Exclusion
- Exfoliation glaucoma, pigmentary glaucoma
- History of acute angle closure
Key Trial Info
Start Date :
November 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2009
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT00312403
Start Date
November 1 2005
End Date
December 1 2009
Last Update
January 15 2010
Active Locations (1)
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1
Department of Clinical Pharmacology
Vienna, Austria, 1090