Status:
COMPLETED
RATe Control in Atrial Fibrillation
Lead Sponsor:
Asker & Baerum Hospital
Conditions:
Atrial Fibrillation
Eligibility:
All Genders
18+ years
Phase:
PHASE3
Brief Summary
The purpose of this study is to compare the effect of metoprolol, verapamil, diltiazem and carvedilol on ventricular rate, working capacity and quality of life in patients with chronic atrial fibrilla...
Detailed Description
This is a randomised, single blinded, cross-over study comparing the efficacy of metoprolol 100 mg o.d., verapamil 240 mg o.d., diltiazem 360 mg o.d. and carvedilol 25 mg o.d. in reducing ventricular ...
Eligibility Criteria
Inclusion
- Persistent or permanent atrial fibrillation with ventricular rate \> 80/min at rest and/or \> 100/min average at daytime.
- Male or female, age \> 18.
Exclusion
- Hypersensitivity or contraindication to metoprolol, verapamil, diltiazem or carvedilol.
- Coronary heart disease or heart failure
- Systolic blood pressure \< 100 mmHg
- AV-conduction disturbance
- Severe hepatic or renal dysfunction
- Thyrotoxicosis
- Ongoing treatment with Digitalis
- Pregnancy or lactation
Key Trial Info
Start Date :
April 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT00313157
Start Date
April 1 2006
End Date
September 1 2010
Last Update
May 13 2014
Active Locations (1)
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1
Vestre Viken Hospital Trust, Baerum Hospital
Rud, Akershus, Norway, 1309