Status:
COMPLETED
Sources of the Variability of the Response to Fluindione in Elderly Patients (PREPA)
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
Institut National de la Santé Et de la Recherche Médicale, France
GIS Institut de la Longévité
Conditions:
Cardiovascular Disease
Eligibility:
All Genders
80+ years
Brief Summary
We propose to study the pharmacokinetic (PK) and pharmacodynamic (PD) components of the response to fluindione, the main oral anticoagulant used in France, in patients over 80. We expect to gain a be...
Detailed Description
Oral anticoagulant drugs have improved the prognosis of patients with thromboembolic disease. However, optimal oral anticoagulation control is usually hampered by significant interindividual variabili...
Eligibility Criteria
Inclusion
- Patients over and including 80 years old
- Hospitalised in one of the recruiting centers
- Initiating a treatment with fluindione (either first time or after more than 15 days holidays)
Exclusion
- Contraindication to fluindione or one of its components
- Patients receiving other medications known to interfere with fluindione and preventing its use
- Patients with physical or mental impairment preventing them from signing the consent form
- Patients whose length of stay in hospital is less than 3 days
Key Trial Info
Start Date :
September 1 2005
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2008
Estimated Enrollment :
152 Patients enrolled
Trial Details
Trial ID
NCT00313469
Start Date
September 1 2005
End Date
April 1 2008
Last Update
August 25 2011
Active Locations (2)
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1
CHU d'Angers
Angers, France, 49000
2
Hôpital Bichat-Claude Bernard
Paris, France, 75018