Status:
COMPLETED
MAST - Magnesium for Sickle Cell Acute Crisis in Children
Lead Sponsor:
The Hospital for Sick Children
Collaborating Sponsors:
The Physicians' Services Incorporated Foundation
Conditions:
Anemia, Sickle Cell
Eligibility:
All Genders
4-18 years
Phase:
PHASE3
Brief Summary
The purpose of this study is to determine if intravenous magnesium sulfate treatment is effective in reducing the length of stay and pain in children with sickle cell disease suffering an acute vaso-o...
Detailed Description
Sickle cell disease is a group of complex, chronic disorders characterized by hemolysis, acute vaso-occlusive episodes (crises), unpredictable acute complications that can be life-threatening, and the...
Eligibility Criteria
Inclusion
- Known sickle cell disease
- Previous painful crisis resulting in an Emergency Department(ED) visit
- Current visit with a chief complaint of pain
- Age 4 years - 18 years
- Staff ED decides to admit to the hospital
- Staff ED decides to start an intravenous line
Exclusion
- Fever (\>38.5C) during the 24 hours prior to visit at triage
- Patients transfused within 90 days of study entry
- Patients with known renal disease
- Patients with known heart block or myocardial damage
- Patients who take a magnesium-containing medication or calcium channel blocker on a regular basis
- Patients who received anesthetics, cardiac glycosides and neuromuscular blockers during the acute illness in the last 24 hours
- Patients or parents unable to communicate in English
- Known pregnancy
- Known allergy to Magnesium
- Admission to the ICU
- Enrolment to the study in the last 30 days
Key Trial Info
Start Date :
April 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2013
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT00313963
Start Date
April 1 2006
End Date
July 1 2013
Last Update
August 13 2013
Active Locations (1)
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1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8