Status:
UNKNOWN
Evaluation of the Role of Mesenchymal Stem Cells in the Treatment of Graft Versus Host Disease
Lead Sponsor:
Christian Medical College, Vellore, India
Conditions:
Graft vs Host Disease
Eligibility:
All Genders
2-60 years
Phase:
PHASE1
PHASE2
Brief Summary
Mesenchymal stem cells (MSC) have been shown to have immunosuppressive properties. Following a bone marrow/peripheral blood stem cell transplant, a proportion of patients develop a condition called 'g...
Detailed Description
A single center non randomized, non blinded Phase I/II clinical trial is proposed to study the role of mesenchymal stem cells (MSC) in the management of steroid refractory graft versus host disease (G...
Eligibility Criteria
Inclusion
- Informed consent obtained from patient and donor
- Any patient who has undergone HLA-matched related allogeneic stem cell transplantation with steroid refractory Grades II-IV acute GVHD
- Prednisolone 2 mg/kg/day (or equivalent doses of methylprednisolone, etc.) for at least one week
Exclusion
- Invasive fungal disease
- Active cytomegalovirus (CMV)/Epstein-Barr virus (EBV)/varicella disease
- Relapsed malignancy
Key Trial Info
Start Date :
June 1 2007
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2008
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT00314483
Start Date
June 1 2007
End Date
June 1 2008
Last Update
July 6 2007
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Department of Haematology, Christian Medical College
Vellore, Tamil Nadu, India, 632002