Status:
COMPLETED
Modafinil as an Adjunctive on Cognitive Functioning in Patients With Schizophrenia
Lead Sponsor:
Laval University
Conditions:
Schizophrenia and Schizophrenia Spectrum Psychosis
Eligibility:
All Genders
18+ years
Phase:
PHASE1
PHASE2
Brief Summary
Patients suffering from schizophrenia and schizophrenia spectrum psychosis frequently experience cognitive impairments. Such deficits may affect memory, attention and executive function processes. Man...
Eligibility Criteria
Inclusion
- To have a diagnosis of schizophrenia or schizophrenia spectrum psychosis (schizophreniform, schizoaffective, delusional trouble, brief psychosis), as defined in Diagnostic and statistical manual of mental disorders (\[DSM-IV\], American Psychiatric Association \[APA\], 1995);
- To be 18 years old or more;
- Psychotic symptoms must be stabilized with a second generation antipsychotic for at least 4 weeks i.e. no item on Positive And Negative Syndrome Scale (\[PANSS\], Kay, Opler, \& Fiszbein, 1987) positive subscale equal or superior to a score of 5.
- Neurocognitive impairments are observed on attention measures. Participants will merit one or more result equal or lower to Z = -1,00 in at least one attention task.(Color trail test part A, MWCT, Stroop test, CPT-II).
Exclusion
- To have a diagnosis of mental retardation (APA, 1994), or medical affection other than schizophrenia or schizophrenia spectrum psychosis, or neurological troubles that can lead to cognitive impairments (ex : temporal epilepsy);
- To have a current diagnosis of panic disorder (DSM-IV);
- To manifest an important suicidal potential according to the psychiatrist clinical judgment;
- To suffer from unstable hypertension, cardiac arrhythmia or any other cardiac disorders;
- To take medications, drugs and/or natural products that have a stimulant effect on the CNS (e.g., cocaine, methylphenidate); and
- To be a pregnant woman, who breast-feed, or a woman who do not use an effective contraceptive (abstinence is considered like an effective method).
Key Trial Info
Start Date :
September 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00314639
Start Date
September 1 2005
Last Update
February 12 2009
Active Locations (1)
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1
Centre Hospitalier Robert-Giffard
Québec, Quebec, Canada, G1J 2G3