Status:
COMPLETED
A Trial of Pentoxifylline for the Treatment of Recurrent Aphthous Stomatitis
Lead Sponsor:
Manchester University NHS Foundation Trust
Conditions:
Recurrent Aphthous Stomatitis
Eligibility:
All Genders
16-65 years
Phase:
NA
Brief Summary
This is a randomized, double blind, placebo controlled trial of the use of pentoxifylline (oxpentifylline) for the treatment of recurrent mouth ulcers.
Detailed Description
There are few effective treatments for recurrent aphthous stomatitis (cancer sores, recurrent mouth ulcers). Most existing treatments are palliative topical treatments. Some systemic drugs e.g. steroi...
Eligibility Criteria
Inclusion
- Diagnosis of minor recurrent aphthous stomatitis
- 2 or more mouth ulcers per month for more than 6
- No current treatment for oral ulceration or willing to stop treatment
- Age 16 to 65 years
Exclusion
- Taking ketorolac, theophylline or anti-hypertensive medication except diuretics (contra-indicated in patients treated with pentoxifylline)
- Systemic diseases that contra-indicate the use of pentoxifylline i.e. pregnancy, hypotension, ischaemic heart disease, acute myocardial infarction, cerebral or occular hemorrhage, renal or hepatic failure, porphyria or allergy to pentoxifylline.
- Patients with an underlying deficiency state or systemic disease that could cause recurrent mouth ulcers e.g. iron, vitamin B12 or foliate deficience, coeliac disease, Crohn's disease, ulcerative colitis, Behcet's disease or Aids.
Key Trial Info
Start Date :
June 1 1996
Trial Type :
INTERVENTIONAL
End Date :
November 1 1998
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT00315679
Start Date
June 1 1996
End Date
November 1 1998
Last Update
August 3 2018
Active Locations (1)
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1
University Dental Hospital of Manchester
Manchester, United Kingdom, M15 6FH