Status:
COMPLETED
Addition of Quetiapine in Obsessive Compulsive Disorder - Westenberg Study
Lead Sponsor:
AstraZeneca
Conditions:
Obsessive Compulsive Disorder
Eligibility:
All Genders
18-70 years
Phase:
PHASE2
Brief Summary
Quetiapine (Seroquel ®), an atypical antipsychotic registered for use in schizophrenia, which has a very low propensity of extrapyramidal and endocrine side-effects, has also been studied as an adjunc...
Eligibility Criteria
Inclusion
- All patients meet the DSM IV criteria for obsessive-compulsive disorder
- Y-BOCS score \> 16 if obsessions and compulsions
- Y-BOCS score \> 10 if only obsessions
- Y-BOCS score \> 10 if only compulsions
- Male and female, aged between 18-70 years
- Female patients of childbearing potential must have a negative pregnancy test and use a reliable method of contraception.
- Written informed consent
Exclusion
- Presence of any of the following DSM IV conditions; major depression (with a HDRS\>15, \[17 item\]), bipolar disorder, schizophrenia or any other psychotic condition, tic disorder, substance related disorder during the past 6 months, epilepsy, or any structural CNS disorder or stroke within the last year.
- Evidence of clinically significant and unstable cardiovascular, gastro-intestinal, pulmonary, renal, hepatic, endocrine or haematological disorders, glaucoma, myocardial infarction within the past year, or micturition abnormalities
- Patients at risk for suicide
- Multiple serious drug allergies or known allergy for the trial compounds
- Use of antipsychotics during 6 months before the screening visit
- Use of any other psychotropic drug during 6 months before the screening visit
- Cognitive and behavioural treatment 3 months prior to the screening visit
- Any known contra-indication against citalopram or quetiapine
Key Trial Info
Start Date :
December 1 2003
Trial Type :
INTERVENTIONAL
End Date :
August 1 2006
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT00318539
Start Date
December 1 2003
End Date
August 1 2006
Last Update
January 21 2011
Active Locations (1)
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1
Research Site
Utrecht, Netherlands