Status:
ACTIVE_NOT_RECRUITING
Kidney and Blood Stem Cell Transplantation That Eliminates Requirement for Immunosuppressive Drugs
Lead Sponsor:
Stanford University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Immune Tolerance
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
PHASE2
Brief Summary
The Stanford Medical Center Program in Multi-Organ Transplantation and the Division of Bone Marrow Transplantation are enrolling patients into a research study to determine if blood stem cells injecte...
Detailed Description
The purpose of this study is to determine the proportion of patients that can be withdrawn completely from immunosuppressive drugs while maintaining normal function of HLA-matched living related donor...
Eligibility Criteria
Inclusion
- Kidney transplant performed at Stanford University Medical Center
- Have an HLA-matched sibling donor
- No known contraindication to administration of rabbit ATG or radiation
- Willing to use a reliable form of contraception for at least 24 months following transplantation
Exclusion
- Previous treatment with rabbit ATG or a known allergy to rabbit proteins
- History of cancer, other than non-melanoma skin cancer
- Pregnant or breastfeeding
- HIV, Hepatitis B, or Hepatitis C infection
- Previous organ transplant
- Leukopenia (white blood cell count less than 3000/mm³)
- Thrombocytopenia (platelet count less than 100,000/mm³)
- cPRA\>80%
Key Trial Info
Start Date :
July 1 2004
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT00319657
Start Date
July 1 2004
End Date
July 1 2026
Last Update
June 18 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Stanford University, School of Medicine
Stanford, California, United States, 94305