Status:
WITHDRAWN
Intravenous (IV) Lidocaine for Opioid-refractory Pain
Lead Sponsor:
San Diego Hospice & Palliative Care
Conditions:
Neoplasms
Pain
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Opioid medicines, like morphine, are the main treatment for severe cancer pain. Unfortunately, some patients suffer severe pain despite high doses of opioids. We hypothesize that intravenous lidocaine...
Detailed Description
Pain is a pervasive symptom among advanced cancer patients. In addition to pain's negative impact, unrelieved pain is linked to depression and precludes patients from dealing with other aspects of lif...
Eligibility Criteria
Inclusion
- Inclusion Criteria
- Advanced cancer patient (prognosis ≤6 mos)
- Age ≥ 18 years old
- Opioid-refractory pain
- Steady state levels of adjunctive pain medications
- Intravenous access
- Has decision-making capacity
- Hemodynamics: 85\<SBP\<210 mm Hg \& 55\<HR\<120
- EKG QTc ≤ 440 msec
- Exclusion Criteria
- Methadone use
- Myoclonus
- Seizure disorder
- History of ventricular arrhythmia
- Allergy to amide local anesthetics
- Evidence of cardiac ischemia by history or EKG
- Currently receiving a parenteral local anesthetic
- Pregnancy
Exclusion
Key Trial Info
Start Date :
May 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2009
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT00321347
Start Date
May 1 2006
End Date
May 1 2009
Last Update
June 22 2012
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
San Diego Hospice & Palliative Care
San Diego, California, United States, 92103-1407