Status:
COMPLETED
Plasticity in Cervical Dystonia
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Cervical Dystonia
Eligibility:
All Genders
18+ years
Brief Summary
This study will identify changes that occur in the part of the brain that controls hand movements in patients with cervical (neck) dystonia. Patients with dystonia have muscle spasms that cause abnorm...
Detailed Description
Objectives The main objective of this proposal is to evaluate plasticity in patients with cervical dystonia. Neither abnormal Hebbian nor non-Hebbian plasticity has been studied for cervical dystonia...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy volunteers (aged 18 or older) who are willing to participate
- Patients (aged 18 and older) with idiopathic cervical dystonia that show a clear asymmetric involvement of the SCM muscles with lateral rotation of the head in the coronal or longitudinal plane
- EXCLUSION CRITERIA:
- Subjects with additional significant neurological disorder, current use or a history of alcohol or drug abuse, psychiatric disorder requiring hospitalization or prolonged treatment such as substance abuse addiction, head injury with loss of consciousness, epilepsy.
- Subjects with significant hearing loss
- Subjects receiving drugs with significant action on the central nervous system
- Subjects who have been treated with botulinum toxin injections less than 3 months prior to their participation in the study
- Subjects who are taking any oral medication for dystonia at the time of the study
- The following exclusion criteria are due to the use of transcranial magnetic stimulation:
- Subjects with cardiac pacemakers, implanted medication pumps
- Subjects with eye, blood vessel, cochlear, or eye implants
- Subjects with increased intracranial pressure as evaluated by clinical means
- Subjects with metal in the cranium
- Subjects with dental braces (but dental fillings are acceptable), metal fragments from occupational exposure or surgical clips in or near the brain
Exclusion
Key Trial Info
Start Date :
May 5 2006
Trial Type :
OBSERVATIONAL
End Date :
May 20 2008
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT00323765
Start Date
May 5 2006
End Date
May 20 2008
Last Update
July 2 2017
Active Locations (1)
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1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892