Status:
COMPLETED
Long-Term Motor Learning in Focal Hand Dystonia
Lead Sponsor:
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Focal Hand Dystonia
Eligibility:
All Genders
18+ years
Brief Summary
This study will examine the effects of long-term practice of repeated finger movements in people with focal hand dystonia, as compared with healthy volunteers. Patients with dystonia have muscle spasm...
Detailed Description
OBJECTIVE: The overall goal of this proposal is to provide new insights into long-term motor learning by studying patients with focal hand dystonia (FHD) and healthy controls. Long-term motor learnin...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- Healthy volunteers:
- Age 18 years and older
- Right-hand dominant (Edinburgh Handedness Quotient greater than 60)
- Able to provide consent for the protocol
- Patients:
- Age 18 years and older
- Right hand dominant (Edinburgh Handedness Quotient greater than 60)
- Idiopathic focal hand dystonia in right hand
- Able to provide consent for the protocol
- EXCLUSION CRITERIA:
- Subjects with other medical, surgical, neurologic or psychiatric conditions
- If participants are taking certain centrally acting medications (like antidepressants, anxiolytics/neuroleptics, anticonvulsants, antipsychotics, antiparkinson, hypnotics, stimulants, and/or antihistamines) may not be eligible to participate in this study.
- The presence of a cardiac pacemaker, an implanted medical pump, a metal plate or metal object in skull or eye is contraindications for TMS application.
- Patients with seizure disorder or epilepsy
- Subjects without the capacity to give informed consent
- If participation in the study would, in the opinion of the investigators, cause undue risk or stress for reasons such as excessive fatigue, general frailty, or excessive apprehension
- Patients:
- Subjects with any abnormal findings on neurological examination (except right hand), and general physical examination
- Secondary hand dystonia
- Healthy volunteers:
- Subjects with any abnormal findings on neurological examination and general physical examination
- Subjects who have learned to play the piano or any other keyboard instrument in the past.
- Subjects who have jobs or are involved in daily activities that demand skilled, fine-finger movements
Exclusion
Key Trial Info
Start Date :
May 9 2006
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 6 2014
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT00325091
Start Date
May 9 2006
End Date
January 6 2014
Last Update
December 17 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States, 20892