Status:
COMPLETED
Using Intensity Modulated Radiation Therapy (IMRT) for Brain Metastases
Lead Sponsor:
Sidney Kimmel Cancer Center at Thomas Jefferson University
Conditions:
Neoplasm Metastasis
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
The purpose of this study is to determine if using intensity modulated radiation therapy for brain metastases is safe and will improve local control more than standard whole brain radiation therapy.
Detailed Description
Traditionally, whole brain radiation therapy (WBRT) has been the primary therapy for patients with brain metastases. Despite this therapy, patients still have poor survival of four to six months. Untr...
Eligibility Criteria
Inclusion
- Histologically confirmed malignancy
- 2-5 parenchymal brain metastases on magnetic resonance imaging (MRI) with a maximum size of 4 cm
- Partial resection allowed. Complete resection allowed only in patients with more than 3 lesions.
- Karnofsky Performance Status (KPS) equal to or greater than 60
- Neurologic function equal to or greater than 2
Exclusion
- Recurrent brain tumors
- Major medical or psychiatric illnesses
- Metastases in brainstem, midbrain, pons, or medulla
- Patients with leukemia or lymphoma
Key Trial Info
Start Date :
October 1 2005
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2011
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00328575
Start Date
October 1 2005
End Date
June 1 2011
Last Update
October 21 2016
Active Locations (1)
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1
Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107