Status:
COMPLETED
Effects of Statin Medications on Mental Processes, Behavior, and Serotonin Levels
Lead Sponsor:
University of California, San Diego
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Dyslipidemias
Eligibility:
All Genders
20+ years
Phase:
PHASE4
Brief Summary
Statins are cholesterol-lowering medications that are often prescribed for individuals with high cholesterol and who are at risk for heart disease. Preliminary research has shown that statins may have...
Detailed Description
Individuals at risk for coronary artery disease are often prescribed statins, which are medications that reduce the amount of cholesterol in the blood. By lowering cholesterol levels, these individual...
Eligibility Criteria
Inclusion
- LDL cholesterol level between 115-190 mg/dL
- Able to fast prior to blood draw
- Able to comfortably read and write in English
- Able and willing to refrain from donating whole blood during study participation
- Willing to abstain from consuming large amounts of grapefruit juice
Exclusion
- Current use of lipid-lowering medications
- Symptomatic atherosclerotic disease, such as coronary artery disease, kidney failure or insufficiency, peripheral arterial disease, or cerebrovascular disease
- Cancer
- HIV infected
- Medical or psychiatric condition that prevents full study participation or follow-up (e.g., active psychosis)
- Active liver disease or unexplained persistent elevated transaminase levels
- Major surgery or hospitalization in the 3 months prior to study entry
- Current use of cyclosporin, erythromycin, clarithromycin, nefazodone, or any "azole" antifungals, including fluconazole, itraconazole, ketoconazole, mibefradil, or protease inhibitors
- Female of childbearing potential
- Current participation in another clinical trial
Key Trial Info
Start Date :
April 1 2000
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2004
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT00330980
Start Date
April 1 2000
End Date
March 1 2004
Last Update
March 20 2014
Active Locations (1)
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1
University of California, San Diego
La Jolla, California, United States, 92093-0995