Status:
UNKNOWN
Mitochondrial Functions and Oxidative Stress in ALS Patients
Lead Sponsor:
University Hospital, Clermont-Ferrand
Collaborating Sponsors:
University Hospital, Limoges
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Conditions:
Amyotrophic Lateral Sclerosis
Eligibility:
All Genders
30+ years
Brief Summary
In Amyotrophic Lateral Sclerosis (ALS), malnutrition is frequent (16 to 50 % of the patients) and is an independent prognostic factor. One of the implicated factors is the increase of resting energy e...
Detailed Description
In Amyotrophic Lateral Sclerosis (ALS), malnutrition is frequent (16 to 50 % of the patients) and is an independent prognostic factor. One of the implicated factors is the increase of resting energy e...
Eligibility Criteria
Inclusion
- male or female
- age \> 30 years
- definite or probable ALS according to the El Escorial criteria, bulbar or spinal form, ALS diagnosis \< 1 year and treatment by riluzole.
Exclusion
- family history of ALS,
- oral, enteral or parenteral nutritional supply,
- vitamin or trace element supplementation
- confusing illness (cancer, diabetes, chronic infectious or inflammatory disease,thyroid disorders, recent surgery...),
- current tobacco use,
- alcoholism
- treatment by corticosteroids,
- diuretics,
- anorectics
- NSAIDs
- cytotoxics
- anticoagulants...
Key Trial Info
Start Date :
February 1 2006
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2008
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT00331812
Start Date
February 1 2006
End Date
February 1 2008
Last Update
January 19 2011
Active Locations (1)
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1
Clermont-Ferrand University Hospital
Clermont-Ferrand, Auvergne, France, 63000