Status:
COMPLETED
Study to Prevent Cartilage Damage Following Acute Knee Injury.
Lead Sponsor:
Duke University
Conditions:
Knee Injury
Eligibility:
All Genders
18-30 years
Phase:
PHASE1
PHASE2
Brief Summary
Individuals who have had a severe knee injury have an increased risk of developing arthritis of the knee and at a much earlier age than would otherwise be expected. The swelling and inflammation that ...
Detailed Description
Osteoarthritis is highly prevalent with significant impact on health care utilization and personal suffering. Injury predisposes to OA even after surgical correction (1, 2). Definitive therapy for est...
Eligibility Criteria
Inclusion
- Onset of injury less than 4 weeks prior to evaluation
- Severe knee injury that requires surgery, including anterior cruciate ligament tear, meniscus tear and chondral injury
- BMI less than 30
- Age 18-30
- Women will have serum pregnancy testing (bHCG) at time of entry and on follow-up evaluation and must agree to use an approved form of contraception during the study period.
Exclusion
- Prior signal joint injury requiring medical evaluation
- History of arthritis or rheumatic disease
- History of intra-articular corticosteroid in index joint
- Septic joint
- Evidence of chronic joint disease by plain radiograph
- Fracture or multiple ligament tear
- Pregnancy or lactation
- Inability to give informed consent
Key Trial Info
Start Date :
March 1 2006
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2007
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT00332254
Start Date
March 1 2006
End Date
June 1 2007
Last Update
May 30 2013
Active Locations (1)
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1
Duke University Sports Medicine Clinic
Durham, North Carolina, United States, 27710